Oct 16, 2014 paragonimiasis is a foodborne infection caused by paragonimus parasites. Sep, 2016 paragonimiasis is an important and widespread neglected tropical disease. Since discovery of this lung fluke in 1878 by kerbert, paragonimus westermani has been found to occur in many parts of asia. A paragonimus westermani centered venn diagram of 12,852 predicted proteins. Paragonimus westermani ova in pleural effusion, diagnostic. Among the paragonimus species, only paragonimus westermani has a triploid variant, which can produce ova via parthenogenesis. A recombinant protein of paragonimus westermani yolk ferritin was bacterially produced from a previously cloned complementary dna and was used as an antigen for an enzymelinked immunosorbent assay elisa against paragonimiasis and other helminthinfected sera to evaluate its serodiagnostic potential.
Trematoda ini mempunyai nama lain the lung fluke, distoma westermani, dan paragonimus ringeri. Radiologic findings from these 78 patients were correlated with the pathologic and radiologic findings from a study of experimentally induced pulmonary paragonimiasis in. The life cycle involves two intermediate hosts, the first a freshwater snail and the second a freshwater. Paragonimus kellicotti in north america and paragonimus westermani in asia are generally asymptomatic fluke infections in fisheating species. More than 30 species of trematodes flukes of the genus paragonimus have been reported which infect animals and humans. Laboratory diagnostics of paragonimus westermani and treatment. Fifteen paragonimus species are human pathogens, but two of these, paragonimus westermani and p. Paragonimus westermani is the most impor tant and widely distributed of the many paragonimus species that exist. According to the product label pdf icon external icon, there are no data on the presence of triclabendazole in human. Paragonimus westermani indonesian medical laboratory. Examining human paragonimiasis as a differential diagnosis to tuberculosis in the gambia. Paragonimus westermani is the most common cause of lung fluke infection pleuropulmonary. Pulmonary paragonimiasis is a disease caused by the presence within the lung parenchyma of the oriental lung fluke, paragonimus westermani. They are reddish brown, plump bodied and shaped like coffee beans.
Despite their medical and economic significance, there is limited information on the gene content and expression of paragonimus lung flukes. Endemic in asia and india 40 paragonimus westermani egg lung flukes from biochemist 102 at windsor som. The elisa revealed that paragonimiasis westermani had. Download the annual government request for triclabendazole form. Anti paragonimus westermani antibodies were detected in 4 heads areas b and c in a total of 148 sika deer cervus nippon centralis captured in three areas a, b and c in gifu prefecture. Clinical features of paragonimiasis cases recently found. Conservation and diversification of the transcriptomes of. Of the 10 or more paragonimus species that are human pathogens, only 8 cause significant infections in humans. Paragonimus westermani show considerable geographic genetic variability, and. Produces vacuolization and disintegration of schistosome tegument, followed by. Paragonimus westermani usually reside in pairs in the lung. Wholegenome sequence of the oriental lung fluke paragonimus.
During the period from october 1996 to november 1998, the infection status of paragonimus westermani metacercariae in freshwater crayfish cambaroides similis collected from bogildo islet, wandogun, chollanamdo, which is known for an endemic area of p. Paragonimus, paragonimus westermani, paragonimus skrjabini. Paragonimiasis, or lung fluke disease, is caused by infection with a number of species of trematodes belonging to the genus paragonimus. We report a case of paragonimus westermani infection caused by eating raw deer meat. Other species of paragonimus can also infect humans and invade subcutaneous. Paragonimus species have been described in the literature. Molecular phylogeographic studies on paragonimus westermani. The primary organs for parasite infestation are the lungs and pleura, therefore most patients present with. As the geographical distribution of paragonimus westermani infestation in humans is generally confined to the far east, and especially to parts of japan, korea, and formosa, it is not expected that the american physician would ordinarily come.
It is difficult to make a diagnosis of ectopic paragonimiasis due to an ignorance of, and unfamiliarity with the disease. Among them, more than 10 species are reported to infect humans, the most common is p. Most cases of paragonimiasis occur throughout eastern china, japan, philippines, south korea and taiwan, southeastern laos, thailand and vietnam, and southwestern china asia and are caused by paragonimus westermani. In the united states, detection of antibodies to paragonimus westermani has helped physicians differentiate paragonimiasis from tuberculosis in indochinese immigrants.
Recent research progress on study of paragonimus westermani in. The use of paragonimiasis disability weight needs to be reconsidered with regard to availability of morbidity data and species variation. Excerpt infestation with the trematode paragonimus westermanii or lung fluke is said to be of common occurrence in china, japan, formosa, and the philippines, where it is the cause of endemic hemoptysis. The parasites utilize two intermediate hosts and a definitive hosts like wild mammals and humans to complete its life cycle. Pubmed is a searchable database of medical literature and lists journal articles that discuss paragonimiasis. North american paragonimiasis caused by paragonimus kellicotti. Although rare, paragonimiasis has been acquired in the united states, with multiple cases reported from the midwest. This is a pdf file of an unedited manuscript that has been accepted for publication. The diagnosis was based on positive results of serologic tests for paragonimus specific antibody or on the detection of eggs in sputum samples. Known variously as endemic hemoptysis, lung distoma and pulmonary distomiasis, the disease was first introduced to medical science approximately 75 years ago following its recognition at the postmortem examination of a. Jul 12, 2019 sumitani m, mikawa t, miki y, nisida k, tochino y, kamimori t, fujiwara h, fujikawa t, nakamura f 2005 a case of chronic pleuritis by paragonimus westermani infection resistant to standard chemotherapy and cured by three additional cycles of chemotherapy. Files are available under licenses specified on their description page. Examining human paragonimiasis as a differential diagnosis.
Paragonimus westermani adalah salah satu trematoda paruparu yang bersifat hermaprodit yang dapat menimbulkan penyakit paragonimiasis. Paragonimiasis is caused by lung flukes of the genus paragonimus. Approximately 20 million people are infected with paragonimus, and approximately 300 million people are at risk, with the vast majority in mainland china kong et al. Click on the link to view a sample search on this topic. The lung fluke, paragonimus westermani kerbert, 1878, is widely distributed in asia, and exhibits much variation in its biological properties. Preparation of colloidal gold immunochromatographic strip for. Paragonimus kellicotti an overview sciencedirect topics.
Recently, however, this disease has been seen in many parts of the world, largely due to increases in the numbers of immigrants and overseas travelers. If you have problems viewing pdf files, download the. The simulated disability weights of paragonimus westermani cases were higher than that of p. History most discoveries made between 18741918 discovered in brazil in 1850 by diesing first described in bengal tigers housed in zoos in hamburg and amsterdam in 1877 coenraad kerbert named the parasite after the manager of the zoo g. Lung outcomes and headache were the top two contributors to disability weight for both species. Paragonimus westermani is the major species of lung fluke that infects humans, causing paragonimiasis. Images in clinical medicine from the new england journal of medicine hemoptysis associated with paragonimus westermani. Preparation of colloidal gold immunochromatographic strip for detection of paragonimiasis skrjabini plos one, dec 2019 ying wang, lifang wang, jianwei zhang, guangxi wang, wenbi chen, lin chen, xilin zhang. The lungs and pleura are the primary sites for the infection. The most common is the oriental lung fluke, paragonimus westermani. Our results indicate that pleurisy with eosinophilia and dominant immunoglobulin ig m antibody are characteristic features of the early stage of paragonimiasis, whereas igg antibody is dominant in the late stage. Ppt paragonimus westermani powerpoint presentation free.
A species of lung fluke infecting humans and other animals, and found chiefly in asia and the far east. The complement fixation cf test has been the standard test for paragonimiasis. Venison, another source of paragonimus westermani infection. Endemic in asia and india 40 paragonimus westermani egg lung. Paragonimiasis, human lung fluke disease, is a foodborne anthropozoonosis caused by the trematodes assigned to paragonimus and is regarded by the world health organization as a neglected tropical. Estimation of disability weight for paragonimiasis. The purpose of this service is to provide distance training on morphologic diagnostic parasitology to professionals engaged in identifying parasites associated with human disease. Dpdx offers a monthly parasitology case study quiz by email. Among them, human infections are caused mainly by 9 species, which include p. Paragonimus lung flukes represent a significant and widespread clinical problem, with an estimated 23 million people infected worldwide. Human infection results from ingestion of raw freshwater crab or crayfish infected with the metacercaria.
All structured data from the file and property namespaces is available under the creative commons cc0 license. Approximately 50 species are described, with at least 7 being human pathogens. Cross, in infectious diseases fourth edition, 2017. Media in category paragonimus westermani the following 10 files are in this category, out of 10 total. Recombinant paragonimus westermani yolk ferritin is a useful. Paragonimus westermani free download as powerpoint presentation. Pleuropulmonary paragonimiasis is a foodborne parasitic disease caused by the lung fluke paragonimus westermani, which is endemic in southeast asia and the far east. Kuliah paragonimus westermani free download as powerpoint presentation. Less frequent, but more serious cases of paragonimiasis occur when the parasite travels to the central nervous system. Ppt paragonimus westermani powerpoint presentation. Paragonimus westermani, the oriental lung fluke, belongs to the family troglotrematidae and is one of several digeneans of the same genus that infect the human respiratory tract. The first report of human infection was from taiwan during the latter part of the 19th century.
Paragonimiasis, or lung fluke disease, is caused by infection with a number of species. Paragonimus is a lung fluke flatworm that infects the lungs of humans after eating an infected raw or undercooked crab or crayfish. Recombinant paragonimus westermani yolk ferritin is a. Paragonimus westermani is the major species of lung fluke that infects humans, causing.
Paragonimiasis, also known as paragonimus infection, publications. The purpose of this study was to evaluate the clinical and radiologic features of recently diagnosed pulmonary. More than 30 species of trematodes flukes of the genus paragonimus have been. Paragonimus westermani also known as the oriental lung fluke. Paragonimus westermani was discovered when two bengal tigers died of paragonimiasis in zoos in europe in 1878. We retrospectively analyzed clinical features in 30 patients who were referred to our laboratory and given a diagnosis of paragonimus westermani infection in 1999. Cdc paragonimiasis resources for health professionals. Read paragonimus westermani ova in pleural effusion, diagnostic cytopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Paragonimus westermani proteins were mapped to the genome sequences of o.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Among the more than 10 species reported to infect humans, the most common is p. As the geographical distribution of paragonimus westermani infestation in humans is generally confined to the far east, and especially to parts of japan, korea, and formosa, it is not expected that the american physician would ordinarily come in contact with patients harboring these parasites. Paragonimiasis is a foodborne infection caused by paragonimus parasites, such as paragonimus westermani and paragonimus skrjabini miyazakii. Previous phylogenetic studies using dna sequences have demonstrated that samples from northeast asia form a tight group distinct from samples from south asia philippines, thailand, malaysia. A cysteine protease of paragonimus westermani eggs the. Udomsak silachamroon, yupaporn wattanagoon, in hunters tropical medicine and emerging infectious diseases tenth edition, 2020.
A case of paragonimiasis westermani infection caused by. Cutaneous paragonimiasis due to triploid paragonimus. Known variously as endemic hemoptysis, lung distoma and pulmonary distomiasis, the disease was first introduced to medical science approximately 75 years ago following its recognition at the postmortem examination of a bengal tiger. Jan 17, 2019 to download pdf you need some things, like my website and the name of the file. Paragonimiasis more than 30 species of trematodes flukes of the genus paragonimus have been reported to infect animals and humans. Case series of paragonimiasis from nepal oxford medical. Less frequent, but more serious cases of paragonimiasis occur when the parasite travels to the central nervous system instead of the lungs. Conservation and diversification of the transcriptomes of adult.
Possibility of paragonimiasis due to consumption of raw. Paragonimiasis is a typical foodborne parasitic zoonosis caused by infection with paragonimus spp p. Recently, along with the development of biochemical and molecular immunological techniques, the diagnosis methods have been improved in which preparing. Paragonimiasis is a parasitic lung infection caused by lung flukes of the genus paragonimus, with most cases reported from asia and caused by p.
Paragonimus westermani an overview sciencedirect topics. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Some tens of species have been described, but they are difficult to distinguish, so it is not clear how many of the named species may be synonyms. Pathology once in the lung or ectopic site, the worm stimulates an inflammatory response that allows it to cover itself in granulation tissue forming a capsule. Paragonimiasis genetic and rare diseases information. First described in bengal tigers housed in zoos in hamburg and amsterdam in 1877. The first case described in humans was at autopsy in taiwan in 1879, when adult flukes were found in the lung.
Human infections are most common in eastern asia and in south america. A free powerpoint ppt presentation displayed as a flash slide show on id. The species sometimes is called the japanese lung fluke or oriental lung fluke. Hemoptysis associated with paragonimus westermani nejm. Although rare, paragonimiasis has been acquired in the united states, with multiple cases reported from the midwest and an extensively. The majority of human paragonimus infections can be attributed to the paragonimus westermani species complex, mainly in southeast asia and japan. The four included trematode species shared a core set of 7,599 proteins. Paragonimiasis is a typical foodborne parasitic disease that is common in southeast asia, the far east, latin american, and africa.